Loading...
HomeMy WebLinkAbout07.0- Public Comment Understanding the attacks on Medical Marijuana Dispensaries in San Bernardino and the county. Building code trumps medical necessity and the will of the citizens. Background- The impact of criminalizing the treatment of Cancer and PTSD with i Medical Marijuana since 1996 in the city and county of San Bernardino. A gulf war Veteran commits suicide every hour in America. These are the successful suicides where the Veteran ends up dead by their own hands. The attempted suicides could easily be three times this number. The total number of PTSD veterans now exceeds 1,000.000 Americans. Based on Demographics of former military personnel to general population for the city and county, PTSD veterans in the county far exceeds 1,000 and 100 for the city of San Bernardino. The resulting death tolls at the county and city for denying Medical marijuana since legalization in 1996 approaches 200 at the county level and 20 for the city (officially) Of course the impact on PTSD veterans in destroyed lives and families, far exceeds 100 times these numbers over the 18 years. How effective is marijuana in the treatment of cancer? What we know is that the government admits that over 200 per 100,000 die from cancer every year in America and 301% of those cancer deaths are from starvation. We also know that CBD has produced significant results in the shrinkage of tumors in limited applications. The state of California completed a 20 year study on the effectiveness of marijuana as an anti-nausea in the Therapeutic Cannabis Research project that revealed an 88% survival rate of Cancer patients that had rejected all other antimetrics. It is believed that the widespread us of Cannabis in cancer treatment could reduce cancer deaths in America by 120,000 to 1S0,000 per year. Translating these numbers to the county and city of San Bernardino place the death tolls from denying medical marijuana to cancer patients at 1,200 and 120 per year and since the voter approved initiative in 1996 over 20,000 for the county and 2,000 in the city. Entered Into c; at M �I D� Mtg; by. "' Agen Ite a by. '� . City Clerk Mfecretafy City of San Bernardino While Medical marijuana has many other legitimate medicinal benefits, such as pain treatment and treatment for a host of other illnesses and ailments, the abuse of cancer patients and our Veterans has to be addressed as cold blooded, premeditated murder by our political class and corporate power. At the absolute minimum, these murdering POS include our City Council, Board of Supervisors, Mayor, County CEO, City Manager, City Attorney, the Chief of Police, County Sheriff and the attorneys of Best, Best and Kreiger. The vile copduct of Best, Best and Kreiger cannot be ignored simply as representing the interests of their clients in state and Federal courts. Does anyone actually believe that local and county building code and corporate profits should thump Medical necessity anywhere in America, especially with a voter approved statewide initiative? That is the decision that was passed down by the courts and shows that a lawyer in a black dress is still a lawyer. Justice in these courts will not happen, ever. This war on Marijuana and industrial hemp will not happen without a bloody revolution so it is time to prepare for it. While the road to tyranny is stained with the blood of tyrants and patriots, its paved with the bones of sheep. At the very minimum, we need to open up some MMJ dispensaries owned and operated with PTSD veterans \ cancer patients and defend their right to access and control of their meds with violence. We should also make those responsible for regional attacks on the dispensaries targets for hemp rope justice. r� - 30 C2 The San Bernardino Marijuana Clarity Act To Be Known As The Jesse Act In Memory of the authors son Jesse James Cioci (Preedit) 1992 - 2014 Enter Into Reo. at MC:(.. by- Agenda Item No: �c bv: City Clerk City of San Bernardino Nothing in this ordinance removes the city of San Bernardino ban on medical marijuana dispensaries, instead it clarifies definitions of various cannabis business, and creates a cannabis commission to oversee and regulate cannabis for medical, recreational, and industrial use. This commission will have 90 days to create regulations, or bans through regulations, on various cannabis businesses as described in this act, and more as they may seem fit. Introduction Marijuana, cannabis, weed, whatever you call it, and no matter how you feel about it, is being more accepted daily for both medical and personal recreation use. Medical marijuana came to California in 1996, and San Bernardino has failed to successfully regulate it, leading to our current situation. In 2016 we will be faced with the possibility of age restricted recreational and full legalization of marijuana. I believe that San Bernardino needs a "Cannabis Commissioner"to work with the city code enforcement, law enforcement, managers office, and the city attorney. To ensure health and safety as well as financial and legal issues are addressed, and to be a educational resource for the community. This office would be the oversight and regulatory agency for all things cannabis related,medical, recreational, and industrial, for the city of San Bernardino. Its first action would be to work with an 11 member commission,to create regulations, or to ban through regulation, all areas of the cannabis market. The Mayor and Common Council of the City of San Bernardino do ordain as follows: Whereas, Section 40(z) of the city charter vests the Mayor and Common Council with the power to make and enforce all laws and to regulations with municipal affairs, subject only to the restrictions and limitations provided in the charter or by State law; AND, Whereas, Proposition 215,the California Compassionate Use Act, was enacted by the voters and took effect on November 6 1996 as California Health and Safety code 11362.5; AND Whereas, SB420, a legislative statute, went into effect on January 12004 as California Health and Safety code 11362.7-83 This law broadens Prop 215 to include transportation and other offenses, allows patients to form medical cultivation collectives or cooperatives and established a voluntary ID card system run by the State and County Health Departments; AND Whereas, In February 2007 the California State Board of Equalization(BOE) issued a special notice confirming its policy of taxing medical marijuana transactions, as well as its requirement businesses engaged in such transactions hold sellers permits; AND Whereas, In August 2008 the California State Attorney General released the Guidelines for the Non- Diversion of Marijuana Grown for Medical Use. These guidelines define the lawful operation of Non-profit cooperatives and collectives (sec 4A&B) and provides law enforcement with tools to identify illegal dispensaries; AND Whereas, in April 2011 the city of San Bernardino adopted an ordinance adding San Bernardino municipal code chapter 5.05 prohibiting the establishement and operation of medical marijuana dispensaries; AND Whereas, San Bernardino municipal code section 19.06.026 2B defines medical marijuana dispensaries to be "any business, association, cooperative, club, co-op, delivery service, collective, and any similar use, involved in the sale, possession, cultivation, use, and/or distribution of marijuana for medical purposes; sometimes referred to as a medical marijuana clinic." Now therefore,the Mayor and Common Council of the city of San Bernardino do ordain as follows: Section 1. San Bernardino municipal code section 19.06.026(development code) 2B is hereby amended to read as follows: Medical marijuana clinic is a doctor office specializing in cannabis therapy. It is where a patient obtains a recommendation for medical marijuana use. While, they do not provide marijuana, they are a part of the distribution chain. Collectives and Cooperatives are NON-profit, or NOT-for profit, medical cannabis access points, operating within the California state Attorney Generals Guidelines for the Non-diversion of Marijuana grown for Medical Use. Delivery service is a collective or cooperative that has caregivers who have been certified by the County of San Bernardino in the field of in home health care. Dispensaries are marijuana access points, operating outside of the California state Attorney Generals Guidelines for the Non-diversion of Marijuana Grown for Medical Use. Sometimes referred to as pot shops or recreational marijuana shops. Marijuana processing facility is a facility involved with the cultivation,trimming, extraction of oils, or a kitchen certified by the county health department involved with the preparation of cannabis edibles, for distribution through collectives, cooperatives or dispensaries. Cannabis Cafes or coffee shops are establishments that allow on site consumption. Similar to bars, hookah lounges, or cigar clubs. Cannabis farmers markets and events are functions held temporally on public or private property, sometimes involving on site consumption, similar to traditional farmers markets, concerts, and trade shows. Most often occurring at the National Orange Show grounds. Section II. The city of San Bernardino shall create a position within the city managers office to be the Executive Directer( Cannabis Commissioner) of an 11 member cannabis commission. 3 members will be representatives of 3 separate marijuana businesses 2 members will be medical marijuana patients who are not representatives of a marijuana businesses. Selected by the author 1 member will be a representative of the school board. Selected by city council 1 member will be a representative of law enforcement. Selected by the city attorney 1 member will be a city council member. Selected by the Mayor The remaining members will be representatives of neighborhood associations, businesses associations, religious associations, or members of the community. Selected by city council The three (3)marijuana businesses that wish to be on this commission will be selected by the Inland Empire Collective Association(IECA). The IECA will make a one time payment of $3000,to be deposited into the city's general fund. The remaining 8 members of the commission will receive a monthly payment of$125 each, to be paid from the city's general fund. The Executive Directors salary will be established by the city manager and approved by council. Staff and clerical personnel may be appointed as necessary. The author volunteers for this position, unpaid for the initial 90 days. This commission will have 90 days to write an ordinance, to regulate, or ban marijuana businesses, medical, recreational, and industrial, to define this commissions duties and procedures , and to be self funded after the initial 90 days. Cannabis and Cannabinoids (PDQ®) -National Cancer Institute Page 1 of 6 National Cancer Institute at the National Institutes of Health Cannabis and Cannabinoids (PDQ®) Entered Into Rec. at MCC Mtg. Health Professional Version by: Agenda Item No, Laboratory/Animal/Preclinical Studies by: City Clerk • Antitumor Effects City of San Bernardino • Appetite Stimulation • Analgesia Cannabinoids are a group of 21-carbon—containing terpenophenolic compounds produced uniquely by Cannabis species(e.g.,Cannabis sativa L.) .[1,2]These plant-derived compounds may be referred to as phytocannabinoids.Although delta-9-tetrahydrocannabinol(THC)is the primary psychoactive ingredient,other known compounds with biologic activity are cannabinol,cannabidiol(CBD), cannabichromene,cannabigerol,tetrahydrocannabivarin,and delta-B-THC.CBD,in particular,is thought to have significant analgesic and anti-inflammatory activity without the psychoactive effect (high)of delta-9-THC. Antitumor Effects One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.[3] During this 2-year study,groups of mice and rats were given various doses of THC by gavage.A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma(HCC)was observed in the mice.Decreased incidences of benign tumors(polyps and adenomas)in other organs(mammary gland,uterus,pituitary,testis,and pancreas)were also noted in the rats.In another study,delta-9-THC,delta-B-THC,and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo.[4] In addition,other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.15-8] Cannabinoids may cause antitumor effects by various mechanisms,including induction of cell death, inhibition of cell growth,and inhibition of tumor angiogenesis invasion and metastasis.[9-12]Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.[13,14] Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death.For example,these compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats,while they protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.[9] http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4/print 5/3/2015 Cannabis and Cannabinoids (PDQ®) -National Cancer Institute Page 2 of 6 The effects of delta-9-THC and a synthetic agonist of the CB2 receptor were investigated in HCC.[15] Both agents reduced the viability of HCC cells in vitro and demonstrated antitumor effects in HCC subcutaneous xenografts in nude mice.The investigations documented that the anti-HCC effects are mediated by way of the CB2 receptor. Similar to findings in glioma cells,the cannabinoids were shown to trigger cell death through stimulation of an endoplasmic reticulum stress pathway that activates autophagy and promotes apoptosis.Other investigations have confirmed that CB1 and CB2 receptors maybe potential targets in non-small cell lung carcinoma[16] and breast cancer.1171 An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death,independent of the CB1,CB2,or vanilloid receptors.CBD inhibited the survival of both estrogen receptor—positive and estrogen receptor—negative breast cancer cell lines,inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic mammary cells.[18] Other studies have also shown the antitumor effect of cannabinoids(i.e.,CBD and THC)in preclinical models of breast cancer.[19,20] CBD has also been demonstrated to exert a chemopreventive effect in a mouse model of colon cancer. [21] In this experimental system,azoxymethane increased premalignant and malignant lesions in the mouse colon.Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions.In in vitro experiments involving colorectal cancer cell lines,the investigators found that CBD protected DNA from oxidative damage,increased endocannabinoid levels,and reduced cell proliferation.In a subsequent study,the investigators found that the antiproliferative effect of CBD was counteracted by selective CB1 but not CB2 receptor antagonists,suggesting an involvement of CB1 receptors.[22] Another investigation into the antitumor effects of CBD examined the role of intercellular adhesion molecule-1(ICAM-1).[12]ICAM-1 expression has been reported to be negatively correlated with cancer metastasis. In lung cancer cell lines,CBD upregulated ICAM-1,leading to decreased cancer cell invasiveness. In an in vivo model using severe combined immunodeficient mice,subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines. [23]Tumor growth was inhibited by 60%in THC-treated mice compared with vehicle-treated control mice.Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects.However, research with immunocompetent murine tumor models has demonstrated immunosuppression and enhanced tumor growth in mice treated with THC.[24,25] In addition,both plant-derived and endogenous cannabinoids have been studied for anti-inflammatory effects.A mouse study demonstrated that endogenous cannabinoid system signaling is likely to provide intrinsic protection against colonic inflammation.[26]As a result,a hypothesis that phytocannabinoids and endocannabinoids may be useful in the risk reduction and treatment of colorectal cancer has been developed.[27-30] CBD may also enhance uptake of cytotoxic drugs into malignant cells.Activation of the transient receptor potential vanilloid type 2(TRPV2)has been shown to inhibit proliferation of human http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4/print 5/3/2015 Cannabis and Cannabinoids (PDQ(X) -National Cancer Institute Page 3 of 6 glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.L311 In an in vitro model,CBD increased TRPV2 activation and increased uptake of cytotoxic drugs,leading to apoptosis of glioma cells without affecting normal human astrocytes.This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells.Also,CBD together with THC may enhance the antitumor activity of classic chemotherapeutic drugs such as temozolomide in some mouse models of cancer.[13,32] Appetite Stimulation Many animal studies have previously demonstrated that delta-9-THC and other cannabinoids have a stimulatory effect on appetite and increase food intake.It is believed that the endogenous cannabinoid system may serve as a regulator of feeding behavior.The endogenous cannabinoid anandamide potently enhances appetite in mice.[33]Moreover,CB1 receptors in the hypothalamus may be involved in the motivational or reward aspects of eating.1341 Analgesia Understanding the mechanism of cannabinoid-induced analgesia has been increased through the study of cannabinoid receptors,endocannabinoids,and synthetic agonists and antagonists.The CB1 receptor is found in both the central nervous system(CNS)and in peripheral nerve terminals. Similar to opioid receptors,increased levels of the CB1 receptor are found in regions of the brain that regulate nociceptive processing.L351 CB2 receptors,located predominantly in peripheral tissue,exist at very low levels in the CNS.With the development of receptor-specific antagonists,additional information about the roles of the receptors and endogenous cannabinoids in the modulation of pain has been obtained. [36,37] Cannabinoids may also contribute to pain modulation through an anti-inflammatory mechanism; a CB2 effect with cannabinoids acting on mast cell receptors to attenuate the release of inflammatory agents,such as histamine and serotonin,and on keratinocytes to enhance the release of analgesic opioids has been described.138-401 One study reported that the efficacy of synthetic CB1-and CB2- receptor agonists were comparable with the efficacy of morphine in a murine model of tumor pain.[41] References 1. Adams IB,Martin BR:Cannabis: pharmacology and toxicology in animals and humans. Addiction 91 (11): 1585-614,1996. [PUBMED Abstract] 2. Grotenhermen F,Russo E,eds.:Cannabis and Cannabinoids: Pharmacology,Toxicology,and Therapeutic Potential.Binghamton,NY:The Haworth Press, 2002. 3. National Toxicology Program: NTP toxicology and carcinogenesis studies of 1-trans-delta(9)- tetrahydrocannabinol(CAS No. 1972-o8-3)in F344 rats and B6C3F1 mice(gavage studies).Natl Toxicol Program Tech Rep Ser 446 O: 1-317, 1996. [PUBMED Abstract] http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4/print 5/3/2015 Cannabis and Cannabinoids (PDQ(X) -National Cancer Institute Page 4 of 6 4. Bifulco M,Laezza C,Pisanti S,et al.: Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 148(2): 123-35, 20o6. [PUBMED Abstract] 5. Sanchez C,de Ceballos ML,Gomez del Pulgar T,et al.: Inhibition of glioma growth in vivo by selective activation of the CB(2)cannabinoid receptor.Cancer Res 61 (15): 5784-9, 2001. [PUBMED Abstract] 6. McKallip RJ,Lombard C,Fisher M,et al.:Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood loo (2): 627-34,2002. [PUBMED Abstract] 7. Casanova ML,Blazquez C,Martinez-Palacio J,et al.: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.J Clin Invest 111(1): 43-50, 2003. [PUBMED Abstract] 8. Blazquez C,Gonzalez-Feria L,Alvarez L,et al.: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas.Cancer Res 64(16): 5617-23,2004. [PUBMED Abstract] 9. Guzman M: Cannabinoids:potential anticancer agents.Nat Rev Cancer 3 (10): 745-55, 2003. [PUBMED Abstract] 1o. Blazquez C,Casanova ML,Planas A,et al.: Inhibition of tumor angiogenesis by cannabinoids. FASEB J 17(3): 529-31,2003. [PUBMED Abstract] 11. Vaccani A,Massi P,Colombo A,et al.: Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144(8): 1032-6, 2005. [PUBMED Abstract] 12. Ramer R,Bublitz K,Freimuth N,et al.:Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.FASEB J 26(4): 1535-48,2012. [PUBMED Abstract] 13. Velasco G,Sanchez C,Guzman M:Towards the use of cannabinoids as antitumour agents.Nat Rev Cancer 12(6):436-44,2012. [PUBMED Abstract] 14. Cridge BJ,Rosengren RJ: Critical appraisal of the potential use of cannabinoids in cancer management.Cancer Manag Res 5: 301-13, 2013. [PUBMED Abstract] 15. Vara D,Salazar M,Olea-Herrero N,et al.:Anti-tumoral action of cannabinoids on hepatocellular carcinoma:role of AMPK-dependent activation of autophagy.Cell Death Differ 18 (7): 1099-111, 2011. [PUBMED Abstract] 16. Preet A,Qamri Z,Nasser MW,et al.:Cannabinoid receptors,CB1 and CB2,as novel targets for inhibition of non-small cell lung cancer growth and metastasis.Cancer Prev Res(Phila)4(1): 65- 75,2011. [PUBMED Abstract] 17. Nasser MW,Qamri Z,Deol YS,et al.: Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion.PLoS One 6 (9): e23901,2011. [PUBMED Abstract] 18. Shrivastava A, Kuzontkoski PM,Groopman JE,et al.: Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 10 (7): 1161-72, 2011. [PUBMED Abstract] 19. Caffarel MM,Andradas C,Mira E,et al.:Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.Mol Cancer 9: 196,2010. [PUBMED Abstract] http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4/print 5/3/2015 Cannabis and Cannabinoids (PDQ®) -National Cancer Institute Page 5 of 6 20. McAllister SD,Murase R,Christian RT,et al.: Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation,invasion,and metastasis.Breast Cancer Res Treat 129(1): 37-47, 2011. [PUBMED Abstract] 21. Aviello G,Romano B,Borrelli F,et al.: Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.J Mol Med(Berl)90 (8): 925-34, 2012. [PUBMED Abstract] 22. Romano B,Borrelli F,Pagano E,et al.: Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.Phytomedicine 21(5): 631-9, 2014. [PUBMED Abstract] 23. Preet A,Ganju RK,Groopman JE: Delta9-Tetrahydrocannabinol inhibits epithelial growth factor -induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 27(3):339-46, 2oo8. [PUBMED Abstract] 24. Zhu LX,Sharma S,Stolina M,et al.: Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated,cytokine-dependent pathway.J Immunol 165(1): 373-8o, 2000. [PUBMED Abstract] 25. McKallip RJ,Nagarkatti M,Nagarkatti PS: Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response.J Immunol 174 (6): 3281-9,2005. [PUBMED Abstract] 26. Massa F,Marsicano G,Hermann H,et al.:The endogenous cannabinoid system protects against colonic inflammation.J Clin Invest 113(8): 1202-9, 2004. [PUBMED Abstract] 27. Patsos HA,Hicks DJ,Greenhough A,et al.: Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans 33(Pt 4): 712-4, 2005. [PUBMED Abstract] 28. Liu WM,Fowler DW,Dalgleish AG:Cannabis-derived substances in cancer therapy--an emerging anti-inflammatory role for the cannabinoids.Curr Clin Pharmacol 5 (4): 281-7, 2010. [PUBMED Abstract] 29. Malfitano AM,Ciaglia E,Gangemi G,et al.: Update on the endocannabinoid system as an anticancer target.Expert Opin Ther Targets 15(3): 297-3o8, 2011. [PUBMED Abstract] 30. Sarfaraz S,Adhami VM,Syed DN,et al.: Cannabinoids for cancer treatment: progress and promise. Cancer Res 68(2): 339-42,2oo8. [PUBMED Abstract] 31. Nabissi M,Morelli MB,Santoni M,et al.:Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents.Carcinogenesis 34(1):48-57, 2013. [PUBMED Abstract] 32. Torres S,Lorente M,Rodriguez-Fornes F,et al.:A combined preclinical therapy of cannabinoids and temozolomide against glioma.Mol Cancer Ther 10 (1): 90-103,2011. [PUBMED Abstract] 33• Mechoulam R,Berry EM,Avraham Y,et al.: Endocannabinoids,feeding and suckling--from our perspective.Int J Obes(Loud)30(Supp11): S24-8, 2oo6. [PUBMED Abstract] 34• Fride E,Bregman T,Kirkham TC: Endocannabinoids and food intake: newborn suckling and appetite regulation in adulthood.Exp Biol Med(Maywood) 230 (4): 225-34, 2005. [PUBMED Abstract] 35• Walker JM, Hohmann AG,Martin WJ,et al.:The neurobiology of cannabinoid analgesia. Life Sci 65(6-7): 665-73, 1999• [PUBMED Abstract] http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4/print 5/3/2015 Cannabis and Cannabinoids (PDQ®) -National Cancer Institute Page 6 of 6 36. Meng ID,Manning BH,Martin WJ,et al.:An analgesia circuit activated by cannabinoids.Nature 395(6700):381-3, 1998. [PUBMED Abstract] 37. Walker JM,Huang SM,Strangman NM,et al.:Pain modulation by release of the endogenous cannabinoid anandamide.Proc Natl Acad Sci U S A 96(21): 12198-203, 1999. [PUBMED Abstract] 38. Facci L, Dal Toso R,Romanello S,et al.: Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc Natl Acad Sci U S A 92(8): 3376-8o,1995• [PUBMED Abstract] 39• Ibrahim MM,Porreca F,Lai J,et al.:CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.Proc Natl Acad Sci U S A 102(8): 3093-8,2005. [PUBMED Abstract] 40. Richardson JD,Kilo S,Hargreaves KM: Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors.Pain 75(1): 111-9,1998. [PUBMED Abstract] 41. Khasabova IA,Gielissen J,Chandiramani A,et al.:CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain. Behav Pharmaco122(5-6): 607-16, 2011. [PUBMED Abstract] Updated: December 17,2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4/print 5/3/2015